What is Kisspeptin?
Kisspeptin is a neuropeptide encoded by the KISS1 gene that plays a central role in the regulation of reproductive hormone signaling. It was first identified in cancer research for its metastasis-suppressing properties, but has since become one of the most studied peptides in reproductive endocrinology. Kisspeptin acts as the upstream trigger for the entire reproductive hormone cascade, making it a critical compound for fertility and endocrine research.
Mechanism of Action
Kisspeptin binds to the GPR54 (KISS1R) receptor on GnRH neurons in the hypothalamus, stimulating the release of gonadotropin-releasing hormone (GnRH). This in turn triggers the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), the two key hormones that regulate gonadal function. Kisspeptin essentially acts as the master switch for reproductive hormone activation.
Research Applications
Kisspeptin is actively studied across several areas of reproductive and metabolic research. These include the regulation of puberty onset, fertility and ovulation signaling, hypogonadism and hormone deficiency models, the relationship between metabolic status and reproductive function, and its original discovery context as a metastasis suppressor in cancer biology. Clinical trials have explored kisspeptin as a diagnostic tool for reproductive disorders and as a potential therapeutic agent for conditions involving impaired GnRH signaling.
Product Details
Storage
Store lyophilised vials in a cool, dry place away from light. Once reconstituted with bacteriostatic water, refrigerate at 2-8°C and use within 3-4 weeks. See our reconstitution guide for detailed instructions.
รีวิว
ยังไม่มีบทวิจารณ์