MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a mitochondrial-derived peptide first identified in 2015. Unlike most peptides which are encoded in nuclear DNA, MOTS-C is encoded in mitochondrial DNA — making it one of the most unique and fascinating compounds in current longevity and metabolic research.
Bangkok Peptide Center supplies MOTS-C in 10mg lyophilised vials for laboratory research use. Each vial is third-party tested at 99%+ purity with Certificate of Analysis available on request.
About MOTS-C
MOTS-C was discovered by researchers at USC and published in the journal Cell Metabolism in 2015. Its identification was groundbreaking because it revealed that mitochondria — long considered only the energy powerhouses of cells — also produce signalling peptides that regulate whole-body metabolism.
MOTS-C primarily acts on skeletal muscle and the liver, where it regulates glucose metabolism and fatty acid oxidation. Research has shown it activates AMPK — one of the master regulators of cellular energy sensing — and influences the folate cycle and methionine metabolism.
Research applications
MOTS-C has attracted significant research interest across several areas:
- Metabolic regulation — glucose uptake and insulin sensitivity in skeletal muscle models
- Exercise mimetic research — studies suggesting it may replicate some metabolic benefits of physical exercise
- Obesity and type 2 diabetes models — effects on fat metabolism and glucose homeostasis
- Longevity research — MOTS-C levels decline with age, mirroring patterns seen with NAD+
- Stress resistance — studies showing improved cellular stress response in animal models
- Bone density — emerging research on effects on osteoblast activity
A particularly interesting area of MOTS-C research involves its potential as an exercise mimetic. Animal studies have shown that MOTS-C administration produces metabolic changes similar to those seen with exercise training — making it a compound of significant interest in metabolic disease research.
MOTS-C and NAD+
MOTS-C and NAD+ are frequently studied together in longevity research contexts. Both are mitochondria-related compounds that decline with age, and their pathways interact through AMPK activation. Bangkok Peptide Center supplies both — see our NAD+ 500mg vials here.
Product specifications
Contents
10mg MOTS-C lyophilised powder per vial
Purity
≥99% — third-party verified
Storage
Cool, dry place away from light. Refrigerate after reconstitution.
Included
Free bacteriostatic water and needles with every order
Delivery
Same-day delivery across Bangkok for orders placed before 12pm. Nationwide express available across Thailand. All orders dispatched in plain, unbranded packaging every day of the week. See our shipping page for full details.
For laboratory research purposes only. MOTS-C supplied by Bangkok Peptide Center is not a medicine, not an approved pharmaceutical product, and is not intended to diagnose, treat, cure, or prevent any disease. Not for human consumption.
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