What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme increasingly recognized as a key regulator of cellular energy metabolism and fat storage. While technically not a peptide, 5-Amino-1MQ is widely studied alongside peptides in metabolic research due to its complementary mechanism of action. NNMT is overexpressed in adipose tissue of obese individuals, and its inhibition has been shown to reverse diet-induced obesity in preclinical models. 5-Amino-1MQ represents one of the most promising new approaches to metabolic research targeting the NAD+ salvage pathway.
Mechanism of Action
5-Amino-1MQ works by selectively inhibiting NNMT, an enzyme that consumes methyl groups from SAM (S-adenosyl methionine) to methylate nicotinamide. When NNMT is overactive, it depletes both SAM and NAD+ levels in cells, leading to reduced cellular energy production and increased fat storage. By blocking NNMT, 5-Amino-1MQ restores intracellular NAD+ concentrations and SAM availability, effectively reactivating metabolic pathways that promote energy expenditure over fat storage. This mechanism is distinct from traditional metabolic compounds and operates at the epigenetic and metabolic crossroads of cellular function.
Research Applications
5-Amino-1MQ has been studied in several metabolic and cellular biology contexts. These include NNMT inhibition and its effects on adipocyte differentiation, diet-induced obesity reversal in preclinical models, NAD+ salvage pathway modulation and cellular energy metabolism, muscle stem cell activation and regeneration, the relationship between NNMT expression and metabolic syndrome, and potential synergistic effects with other metabolic compounds targeting complementary pathways. Research published in Biochemical Pharmacology has demonstrated significant reductions in body weight and fat mass in animal models treated with NNMT inhibitors.
Product Details
Storage
Store lyophilised vials in a cool, dry place away from light. Once reconstituted with bacteriostatic water, refrigerate at 2-8°C and use within 3-4 weeks. See our reconstitution guide for detailed instructions.
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